What to do with a ton of extra memory?

Don't disable your page file. See here.

Try putting portable Firefox on a ramdisk and enjoy a dramatic speed increase. Dataram is free and saves its contents to hard disk when you shut down the computer (and optionally at regular intervals).

If you want, you can try loading some of your most-used programs in a RAM Disk to make them load faster. I tend to just leave it alone and let Superfetch do it's job. When I leave my computer on for a couple days it's not unusual to see it cache 6GB of programs and files.

move the browser cache to RAM disk.

disabling virtual memory is certainly an option, but may have a negative impact on certain programs that explicitly require paging, but then, it's only a few mouse clicks away to turn back on :)