How can I set a keyboard shortcut for accessing Chrome's settings?

You can select it with the menu shortcut. Alt+e will open the Chrome menu and then from there s will open Settings.

There are actually three methods:

• Alt+F then press S
• Alt+E then press S
• F10 then Enter and then press S

Use the clear browser cache shortcut key then escape

Ctrl+Shift+Delete then Esc

Default shortcut on mac chrome is Cmd+,. There should be same or about same on other systems

You can't do it within Chrome as they have not provide any shortcut for this in my knowledge (anyone can correct me if I'm wrong). You have to download the AutoHotKey and then install it on your system, now copy the following script and paste it on notepad and save it with extension .ahk where you can access it easily, now when you launch the Chrome just launch it with that.

SetTitleMatchMode, RegEx

#IfWinActive, - Google Chrome$

^M::
            ControlFocus, Chrome_OmniboxView1


Send chrome://chrome/settings/{Enter}

return

Now when you will press Ctrl+M then it will open the setting page for your Chrome. You can bind other key instead of M, you have to just repalce it with your desired one. Also If you want to use it with Alt key then replace the key ^ with !.

Edit: Also take a look at the Shortcut Manger plugin for Chrome.